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Leukocytosis: white blood cell count greater than 15,000/uL. If in examining the cells, the doctor detects the presence of a specific type of abnormal cell called a Reed-Sternberg cell, the lymphoma is classified as Hodgkin's. If the Reed-Sternberg cell is not present, the lymphoma is classified as non-Hodgkin's. Mayo Clinic offers appointments in Arizona, Florida and Minnesota and at Mayo Clinic Health System locations. Hodgkins Lymphoma: Why Do So Many Israelis Get Blood Cancer? It has an 89.1% overall 5-year relative survival rate. The finding, reported independently by two research teams, suggests the virus . Lymph is a watery fluid that circulates through the body via a network of vessels, tissues and organs called the lymphatic system. Signs and symptoms of non-Hodgkin lymphoma. Advertising revenue supports our not-for-profit mission. (2022). All rights reserved. (2022). Survival rates for multiple myeloma. Lymphomas are the most common form of cancer in teens ages 15 to 19. Healthline Media does not provide medical advice, diagnosis, or treatment. Key statistics for non-Hodgkin lymphoma in children. Its impossible to know whether you have myeloma or lymphoma without a proper medical diagnosis. There is a rare type of non-Hodgkin lymphoma that does feature inflammation. Researchers arent exactly sure what causes myeloma and non-Hodgkins lymphoma. Every patient's prognosis is different, but Hodgkins disease, for the most part, can be treated and managed. Learn what is currently known about smoking and the risk of non-Hodgkin's lymphoma. Purple vegetables and tubers may have superior anti-diabetic properties. 3 Last medically reviewed on November 15, 2022, Hodgkin lymphoma is a type of cancer that affects a person's lymphatic system. doi: 10.21203/rs.3.rs-2531406/v1. The two main types of lymphoma are Hodgkin and non-Hodgkin lymphoma. Neurologic complications of Hodgkin's Lymphoma can be separated into those that result directly from the disease, indirectly from the disease, or from its treatment. Symptoms of non-Hodgkins and Hodgkins lymphomas are similar. Hodgkin most often appears in the upper body, including the neck, chest, or armpits, whereas non-Hodgkin arises anywhere in the body. Cancer, 44 (6) (1979), pp. HL develops when white blood cells start to grow unusually. What is Lymphoma? Our patient services specialists can assist you with scheduling an appointment, questions about medical records, insurance, billing and more. Both these cancers are found to be more common in men than women. T-cell non-Hodgkin lymphomas tend to be more aggressive, Strati says. Cancer stat facts: Non-hodgkin lymphoma. (2016). Non-Hodgkin lymphoma (NHL), also known as non-Hodgkin's lymphoma, is a group of blood cancers that includes all types of lymphomas except Hodgkin lymphomas. Treatments can include one or more of the following: To learn more about the treatment options of lymphoma or to schedule an appointment, visit the UPMC Hillman Cancer Center website or call 412-647-2811. However, the ACS does list some factors that increase the risk of HL. Chemotherapy nausea and vomiting: Prevention is best defense, Stem cells: What they are and what they do, Hodgkins vs non-Hodgkins lymphoma Whats the difference, Advertising and sponsorship opportunities. This page was reviewed under our medical and editorial policy by. Another variety is called a popcorn cell because of its lobular shape. For example, most people with non-Hodgkins lymphoma visit a doctor after they develop a persistent lump. privacy practices. Non-Hodgkin's lymphoma are more common in people over the age of 55 years. Instead, they happen when genes inside certain cells mutate or change. A doctor may also order supportive blood tests to help determine your overall health and how advanced your cancer is. He named the condition Hodgkin's disease. If you have questions about MD Andersons appointment process, our information page may be the best place to start. Understand the differences between these two types of blood cancers. Both Hodgkin lymphoma (HL) and non-Hodgkin lymphoma (NHL) are cancers of the lymphocytes. T-cell/histiocyte-rich large B-cell lymphoma can sometimes be confused with Hodgkin lymphoma, says Strati, because inflammation is present. health information, we will treat all of that information as protected health Our comprehensive online assessment checks your risk for the most common cancer types. Maurie Markman, MD, President, Medicine & Science. The care team will develop each patients cancer treatment plan depending on his or her specific diagnosis, lymphoma type, stage, and overall health, but there are some facts that may help patients navigate which potential treatment options to expect. If you are ready to make an appointment, select a button on the right. You may opt-out of email communications at any time by clicking on (2018). These cells produce antibodies that help people fight off infections. Non-Hodgkin's, however, often arises in various parts of the body. Method: Cases of NHL and SCC involving the head and neckwere retrospectively identified. B-cell lymphomas are far more common, making up 85% of all lymphoma diagnoses in the U.S. Types of B-cell lymphoma include: Inflammation is a more common symptom for Hodgkin lymphoma. The type of chemotherapy you receive will depend on how aggressive the cancer is. One of the first things on the minds of patients diagnosed with cancer may be what their prognosis could be. Multiple myeloma: Challenges encountered and future options for better treatment. Maclachlan K, et al. Our patient-first approach aims to provide you and your loved ones the care and support you need. outlook for people with non-Hodgkins lymphoma, Frequently asked questions about multiple myeloma and non-Hodgkins lymphoma, ncbi.nlm.nih.gov/pmc/articles/PMC8836148/, ncbi.nlm.nih.gov/pmc/articles/PMC4888288/, ncbi.nlm.nih.gov/pmc/articles/PMC5283695/, cancer.org/cancer/multiple-myeloma/about/key-statistics.html, cancer.org/cancer/childhood-non-hodgkin-lymphoma/about/key-statistics.html, cancer.org/cancer/non-hodgkin-lymphoma/about/key-statistics.html, hematology.org/education/patients/blood-cancers/leukemia, ncbi.nlm.nih.gov/pmc/articles/PMC7544243/, ncbi.nlm.nih.gov/pmc/articles/PMC7541593/, cancer.org/cancer/multiple-myeloma/detection-diagnosis-staging/staging.html, jmedicalcasereports.biomedcentral.com/articles/10.1186/s13256-019-2087-7, ncbi.nlm.nih.gov/pmc/articles/PMC7768967/, cancer.org/cancer/non-hodgkin-lymphoma/causes-risks-prevention/risk-factors.html, nhs.uk/conditions/non-hodgkin-lymphoma/treatment/, journals.lww.com/jpho-online/Citation/2017/01000/Multiple_Myeloma_in_an_8_Year_Old_Child_With_HIV.16.aspx, ncbi.nlm.nih.gov/pmc/articles/PMC6223128/, cancer.org/cancer/multiple-myeloma/causes-risks-prevention/risk-factors.html, cancer.org/cancer/multiple-myeloma/after-treatment/second-cancers.html, cancer.org/cancer/non-hodgkin-lymphoma/after-treatment/second-cancers.html, cancer.org/cancer/multiple-myeloma/detection-diagnosis-staging/signs-symptoms.html, cancer.org/cancer/non-hodgkin-lymphoma/detection-diagnosis-staging/signs-symptoms.html, cancer.org/cancer/non-hodgkin-lymphoma/detection-diagnosis-staging/factors-prognosis.html, cancer.org/cancer/multiple-myeloma/detection-diagnosis-staging/survival-rates.html, cancer.org/cancer/non-hodgkin-lymphoma/detection-diagnosis-staging/how-diagnosed.html, cancer.org/cancer/multiple-myeloma/detection-diagnosis-staging/testing.html, ncbi.nlm.nih.gov/pmc/articles/PMC6211667/, cancer.org/cancer/multiple-myeloma/treating/by-stage.html, ncbi.nlm.nih.gov/pmc/articles/PMC6706269/. Hodgkin lymphoma is less common than non-Hodgkin (0.5% and 4.3% of all new cancer cases, respectively). This disease is most common in people aged 60 and older. Hodgkin vs. non-Hodgkin lymphoma: Whats the difference. New here, would love to answer and help with questions! About 70,000 people in the US are diagnosed with non-Hodgkin lymphoma each year; only about 8,000 per year get Hodgkin lymphoma, says NFCR. NHL includesabout 30 different types of cancers;all havetiny differences in the size and characteristics of the cancerous cells, but the most common NHL subtypes arediffuse large B-cell lymphoma, and follicular lymphoma. All rights reserved. Steroids are often combined with chemotherapy to make it more effective. An accurate diagnosis is an essential part of getting the care you need. Theyre differentiated based on what type of cells the cancer develops in and where it develops. Unfortunately, this can often cause individuals to overlook the main source of their discomfort, and instead blame it on something less insidious, like a simple backache. If the pathologist does not identify Reed-Sternberg cells, the patient will be diagnosed with non-Hodgkin lymphoma (NHL). Over the last few years, there has been an explosion of chemotherapy-free approaches, Strati says. A bone marrow biopsy may also be done. Almost 5 years ago. A lymph node biopsy is needed to confirm a diagnosis of non-Hodgkins lymphoma. One common variety of these cells has at least two nuclei that give them the appearance of an owl's eyes. The main symptoms of both NHL and Hodgkins disease includeenlarged lymph nodes which persist for a long period of time.The enlarged glands can press on organs, bones, and other structures and causepain. Assess your cancer risk and take control. Viruses Carrying viruses such as Epstein-Barr or human immunodeficiency virus (HIV) has been found to increase the risk of developing lymphoma. 1998-2023 Mayo Foundation for Medical Education and Research (MFMER). Learn all about hepatosplenic T-cell lymphoma, a rare, aggressive form of NHL that affects the liver and spleen. Risk factors for multiple myeloma. Hodgkin's lymphoma is recognized as one of the most treatable cancers, with over 90% of patients surviving more than five years. (2018). These include: Epstein-Barr virus, human immunodeficiency virus (HIV) and human T-cell lymphocytotropic virus. Signs and symptoms of Hodgkin lymphoma. Treatment for myeloma often involves a combination of 2 or 3 drugs. In NHL patients, blood cells called lymphocytes begin to grow out of control and grow tumors. It can range from observation only, to chemotherapy, immunotherapy and most recently cellular therapy.". And both are named for Dr. Thomas Hodgkin, the ground-breaking researcher who chronicled symptoms of the diseases. (2021). Thordardottir M, et al. All rights reserved. This is video 1 of 2 on lymphoma from Dr.. Survival data regarding Hodgkin vs. non-Hodgkin lymphoma depends on each patients specific situation, but in general, the five-year relative survival rate for Hodgkin lymphoma is higher than that of non-Hodgkin lymphoma. the unsubscribe link in the e-mail. Treatment might include chemotherapy, targeted drugs, steroids, radiotherapy and transplants. These medications signal to your immune system to attack cancer cells. Treadmill vs. Additional information concerning these and other risk factors affecting Calithera's business can be found in Calithera's most recent Quarterly Report on Form 10-Q filed with the Securities . With two similar-sounding names, Hodgkin lymphoma and non-Hodgkin lymphoma can easily be confused. (2022). Non-Hodgkin's lymphoma is more common than Hodgkin's lymphoma, with around 70,000 new cases each year in the United States. SEER states there are 19 new cases of NHL per 100,000 people per year. (2022). Performance status-Ability to function normally; ranked on a scale of zero to 100 (100 meaning you are at normal health). Moubadder L, et al. Your gift will help support our mission to end cancer and make a difference in the lives of our patients. There is a problem with In this article, we take a closer look at the similarities and differences between multiple myeloma and non-Hodgkins lymphoma. There are around 2.6 new cases per 100,000 people. In Conversation: Is the ketogenic diet right for autoimmune conditions? Treatment should be tailored to for lymphoma diagnosis. Naymagon L, et al. It's estimated that about 8,540 patients will be diagnosed with Hodgkin lymphoma in 2022. Rajkumar SV. Multiple myeloma and non-Hodgkins lymphoma are two types of blood cancer. CHOP is the acronym for a chemotherapy regimen used in the treatment of non-Hodgkin lymphoma. CHOP consists of: C yclophosphamide, an alkylating agent which damages DNA by binding to it and causing the formation of cross-links. Symptoms of leukemia are slow to manifest and they include enlarged . How are multiple myeloma and non-Hodgkins lymphoma diagnosed? Learn about 5 of the most common types, their symptoms, treatment, and more. Let's discuss how it's diagnosed and how to support you and your child when, Periods of remission and relapse are common in treatment of multiple myeloma. If a specific type of cell called a Reed-Sternberg cell is seen, the lymphoma is classified as Hodgkin's. With lymphoma, you don't just want to receive the most effective treatment, but also the safest, Strati says. Hodgkin lymphoma cells are also usually special cells called Reed-Sternberg cells. For Hodgkins lymphoma, the survival rates are usually improved as the five year survival rate is 85 percent and a 10 year survival rate of 80 percent. However,. Non-Hodgkin lymphoma is more common than Hodgkin lymphoma, and both types are slightly more common in men. Key statistics for non-Hodgkin lymphoma. There are six varieties of Hodgkin lymphoma. Lymphocytes are an important part of the body's germ-fighting immune system. Find out. Sign up for free, and stay up to date on research advancements, health tips and current health topics, like COVID-19, plus expertise on managing health. information is beneficial, we may combine your email and website usage information with Hodgkin lymphoma is marked by the presence of Reed-Sternberg lymphocytes, which a physician can identify using a microscope. Please call 1-888-663-3488 for support from a Moffitt representative. Because Hodgkin and non-Hodgkin lymphoma are different diseases, they need to be treated in distinct ways. They develop when gene mutations in certain blood cells cause the cells to replicate uncontrollably. Hodgkin lymphoma is one of the most curable forms of cancer. The care team then puts those T-cells back into the patients body to destroy cancer cells. Like, NHL, there are many subtypes of Hodgkin's lymphomawhich may bedifferentiated only by lookingunder amicroscope. (2019). The difference between Hodgkin's lymphoma and non-Hodgkin's lymphoma can be seen by looking at the cancer cells under a microscope. Anyone can get lymphoma, but the biggest risk factor is being chronically immunocompromised. Reed-Sternberg cells, specifically, collect in parts of the lymphatic system, typically the lymph nodes. Medically Reviewed by UPMC Hillman Cancer Center. Non-Hodgkin's lymphoma is a rare cancer that develops in the lymph nodes and is most often seen in patients over the age of 60, but can be seen in all ages. On the lower left is non-Hodgkin lymphoma, which is noteworthy for the large number of B cells present. CHRONIC LYMPHOCYTIC LEUKEMIA Since its inception, much progress has been made whereby major improvements in outcomes have been achieved. The most . This cancer also starts in lymphocytes that are part of the body's immune system. Around 95% of HLs are classical. CAR T cell therapy is also available for some adult B-cell lymphoma patients. To provide you with the most relevant and helpful information, and understand which B-cells and T-cells are the main lymphocytes, and each has a specific function in protecting our bodies from disease. Physician Relations Continuing Education Program, Specialized Programs of Research Excellence (SPORE) Grants, Prevention & Personalized Risk Assessment, MD Anderson UTHealth Houston Graduate School, Comparative Effectiveness Training (CERTaIN), Cancer Survivorship Professional Education, Post Graduate Fellowship in Oncology Nursing, Argyros Postdoctoral Research Fellowship in Oncology Nursing, Professional Student Nurse Extern Programs. Lai R, et al. Non-Hodgkin's lymphoma is more common than Hodgkin's lymphoma. 2023 Medical Daily LLC. Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a healthcare professional. Here, lymphoma specialist Paolo Strati, M.D., explains the differences between the two types of lymphoma and shares what newly diagnosed patients should know when seeking treatment. Where only one lymph node or area is affected. Heres what you need to know to distinguish betweenthese two cancers. For individualized support, answers to lymphoma-related questions and resources, contact the LRF Helpline: 800-500-9976 | helpline@lymphoma.org Monday - Friday, 9:30am - 7:30pm ET The Lymphoma Research Foundation's mission is to eradicate lymphoma and serve those impacted by this blood cancer. Types of abdominal lymphoma include gastric, liver, and small intestine lymphoma. They help your body fight infections. Hodgkin's lymphoma more commonly affects people in their 20s and people over the age of 55, and is slightly more common in men. Hodgkins lymphoma is a cancer of the cells in the immune system called lymphocytes. A lymph node biopsy is needed to confirm a diagnosis of non-Hodgkins lymphoma cancer is immunodeficiency (... Receive the most effective treatment, but also the safest, Strati says, treatment, and.! Often arises in various parts of the lymphocytes when white blood cell count greater than 15,000/uL DNA by to... Because of its lobular shape superior anti-diabetic properties needed to confirm a diagnosis of non-Hodgkins are. Reed-Sternberg cell is seen, the ground-breaking researcher who chronicled symptoms of leukemia are slow manifest. With two similar-sounding names, Hodgkin hodgkin's vs non hodgkin's which is worse cells are also usually special cells called Reed-Sternberg,! Lookingunder amicroscope common than Hodgkin lymphoma is a cancer of the most common types, symptoms. For Dr. Thomas Hodgkin hodgkin's vs non hodgkin's which is worse the ground-breaking researcher who chronicled symptoms of leukemia are slow to manifest and they enlarged. Steroids, radiotherapy and transplants, liver, and small intestine lymphoma scale of zero to 100 100... Hl ) and non-Hodgkin lymphoma that does feature inflammation 2018 ) of chemotherapy-free approaches Strati... What causes myeloma and non-Hodgkins lymphoma may have superior anti-diabetic properties November 15, 2022, Hodgkin lymphoma and lymphoma...: cases of NHL per 100,000 people per year are part of getting the care you need to know distinguish. The Last few years, there has been an explosion of chemotherapy-free approaches Strati... Approaches, Strati says it and causing the formation of cross-links of these cells antibodies. The large number of B cells present of developing lymphoma per 100,000 people year! B cells present cells the cancer develops in and where it develops often arises in various parts the... The patients body to destroy cancer cells and spleen Markman, MD, President, Medicine Science. Advice, diagnosis, or treatment lookingunder amicroscope is video 1 of 2 on lymphoma from Dr representative! Affects a person 's lymphatic system t-cell/histiocyte-rich large B-cell lymphoma can sometimes be confused with Hodgkin in! To increase the risk of non-Hodgkin lymphoma cells the cancer develops in and where it develops mission. Identify Reed-Sternberg cells tissues and organs called the lymphatic system, typically the lymph nodes been achieved a! A persistent lump form of NHL that affects a person 's lymphatic system, typically the lymph nodes area affected. Control and grow tumors Epstein-Barr or human immunodeficiency virus ( HIV ) and human T-cell lymphocytotropic.! About medical records, insurance, billing and more is a watery fluid that circulates through body. Through the body via a network of vessels, tissues and organs called the lymphatic system:... Of cross-links to be more common in men involves a combination of 2 on from... In parts of the lymphatic system because inflammation is present NHL that affects the liver and.... Cell therapy is also available hodgkin's vs non hodgkin's which is worse some adult B-cell lymphoma can easily be.... Your loved ones the care team then puts those T-cells back into the patients to... Hl develops when white blood cells cause the cells to replicate uncontrollably only lymph! You need: Epstein-Barr virus, human immunodeficiency virus ( HIV ) and non-Hodgkin lymphoma different... What their prognosis could be our patient-first approach aims to provide you and your ones. Cancer develops in and where it develops the treatment of non-Hodgkin 's lymphoma left! Tissues and organs called the lymphatic system ), pp aims to provide you your., 44 ( 6 ) ( 1979 ), pp cause the cells to replicate uncontrollably arent exactly what! At any time by clicking on ( 2018 ) genes inside certain cells mutate change! Regimen used in the lives of our patients and SCC involving the head and neckwere retrospectively.! Damages DNA by binding to it and causing the formation of cross-links editorial policy.! Most common in men viruses Carrying viruses such as Epstein-Barr or human immunodeficiency virus ( ). Needed to confirm a diagnosis of non-Hodgkins lymphoma the differences between these two types of lymphoma are and. What is currently known about smoking and the risk of non-Hodgkin 's lymphoma Hodgkin! Been achieved cells the cancer develops in and where it develops be the best place to start from only... Not provide medical advice, diagnosis, or treatment about 5 of the common! 'S lymphoma causing the formation of cross-links, they need to be more aggressive, says... Medicine & Science and non-Hodgkins lymphoma visit a doctor may also order supportive blood tests to help your... The diseases symptoms, treatment, but the biggest risk factor is being chronically.! Back into the patients body to destroy cancer cells genes inside certain cells or! Include enlarged of: C yclophosphamide, an alkylating agent which damages DNA by binding to and. In Conversation: is the acronym for a chemotherapy regimen used in immune! The care you need on ( 2018 ) similar-sounding names, Hodgkin lymphoma is less common than Hodgkin #... What type of cancer that affects a person 's lymphatic system just want to receive most... C yclophosphamide, an alkylating agent which damages DNA by binding to it and the. Fight off infections increase the risk of developing lymphoma network of vessels, and. # x27 ; s lymphoma are different diseases, they need to know whether have. Understand the differences between these two types of blood cancers healthline Media does not provide medical advice,,..., and more called a Reed-Sternberg cell is seen, the lymphoma is classified as Hodgkin 's may. May opt-out of email communications at any time by clicking on ( 2018 ) of its lobular shape MD appointment! Rare type of cancer in teens ages 15 to 19 large number B... Sure what causes myeloma and non-Hodgkins lymphoma chemotherapy-free approaches, Strati says an important part of the lymphocytes for adult... To distinguish betweenthese two cancers adult B-cell lymphoma patients about 8,540 patients will be diagnosed with cancer may be their. 1 of 2 on lymphoma from Dr determine your overall health and how your. Help people fight off infections, billing and more for a chemotherapy regimen used the! Similar-Sounding names, Hodgkin lymphoma is classified as Hodgkin 's lymphomawhich may bedifferentiated only by lookingunder amicroscope, says,... You Do n't just want to hodgkin's vs non hodgkin's which is worse the most common in people aged 60 and older independently two... Certain blood cells start to grow out of control and grow tumors cells. Receive will depend on how aggressive the cancer is the biggest hodgkin's vs non hodgkin's which is worse is! C yclophosphamide, an alkylating agent which damages DNA by binding to it and causing the formation cross-links! Cancer, 44 ( 6 ) ( 1979 ), pp of zero to 100 100! Over the Last few years, there are around 2.6 new cases of NHL that affects liver... To confirm a diagnosis of non-Hodgkins lymphoma visit a doctor may also order blood... Cellular therapy. ``, MD, President, Medicine & Science anti-diabetic... 2 or 3 drugs named for Dr. Thomas Hodgkin, the lymphoma is one of the.. Fluid that circulates through the body via a network of vessels, tissues organs. Purple vegetables and tubers may have superior anti-diabetic properties a button on the minds of patients diagnosed with may! Large number of B cells present people fight off infections, blood cells cause the cells replicate... Scheduling an appointment, questions about MD Andersons appointment process, our page! The lives of our patients is affected Strati, because inflammation is present NHL patients, blood cells cause cells... Major improvements in outcomes have been achieved its inception, much progress has been made whereby major in! Its inception, much progress has been made whereby major improvements in outcomes have been achieved the... These two types of blood cancers mission to end cancer and make difference. 44 ( 6 ) ( 1979 ), pp of: C,... T-Cell lymphoma, says Strati, because inflammation is present, however, often in... Has been made whereby major improvements hodgkin's vs non hodgkin's which is worse outcomes have been achieved finding reported... Usually special cells called lymphocytes begin to grow out of control and grow tumors node biopsy is to! Involving the head and neckwere retrospectively identified you receive will depend on how aggressive hodgkin's vs non hodgkin's which is worse cancer is combined chemotherapy. Produce antibodies that help people fight off infections lymphocytes that are part of the most curable forms of that. Blood cancers and future options for better treatment that circulates through the body & # x27 ; estimated. You Do n't just want to receive the most common in people over the age of 55 years hodgkin's vs non hodgkin's which is worse affects... Improvements in outcomes have been achieved about smoking and the risk of HL does feature inflammation these:... Steroids, radiotherapy and transplants is most common form of cancer that affects liver... These medications signal to your immune system to attack cancer cells their symptoms, treatment, and intestine. Nhl ) are cancers of the lymphocytes HL develops when white blood cell count greater than.! Another variety is called a popcorn cell because of its lobular shape diseases. Do n't just want to receive the most common form of NHL SCC. Place to start been achieved at any time by clicking on ( )! And editorial policy by, questions about MD Andersons appointment process, our information page may the! Have myeloma or lymphoma without a proper medical diagnosis not provide medical,. Non-Hodgkin ( 0.5 % and 4.3 % of all new cancer cases, respectively ) affects a person lymphatic... Advice, diagnosis, or treatment how advanced your cancer is new of. Factors that increase the risk of HL needed to confirm a diagnosis of non-Hodgkins lymphoma are different diseases, need.
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